METHOTREXATE AND MUCOSITIS: A MERRY-GO-ROUND FOR ONCOLOGISTS

Methotrexate and mucositis: A merry-go-round for oncologists

High-dose methotrexate is the backbone 5 Piece Full Upholstered Bedroom of various regimens for treating lymphoid malignancies.Mucositis is a well-known, dose-related side effect of methotrexate.Prophylactic measures such as folinic acid rescue are useful but do not prevent mucositis in all the cases.Once severe mucositis (WHO Grade IV) sets in, mo

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About the shortwave multiple reflections in an urban street canyon building related to three different European climates

Energy exchanges between buildings is affected by urban fabric.As a matter of fact, heat exchange between adjacent buildings is due to convective and radiative heat flows.The main parameters which influence these heat exchange mechanisms are due to climate conditions such as air temperatures/humidity, wind speed/direction and solar irradiance.Most

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The structure of an LIM-only protein 4 (LMO4) and Deformed epidermal autoregulatory factor-1 (DEAF1) complex reveals a common mode of binding to LMO4.

LIM-domain only protein 4 Knit Hats (LMO4) is a widely expressed protein with important roles in embryonic development and breast cancer.It has been reported to bind many partners, including the transcription factor Deformed epidermal autoregulatory factor-1 (DEAF1), with which LMO4 shares many biological parallels.We used yeast two-hybrid assays t

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